Business Guide | Israel-India 2022

2022 < Business Guide < Israel-India F ounded in 2006 to advance the treatment of cancerous tumors, IceCure’s FDA-cleared and CE- marked ProSense ™ Cryoablation System utilizes LiquidNitrogen to destroy benign andmalignant tumors by freezing them to ultra-low temperatures for optimal tumor destruction. Cryoablation for Breast Cancer Cryoablation offers women with certain types of early- stage breast cancer a minimally invasive, in-office treatment that lasts about an hour with superior cosmetic results. Under ultrasoundguidance, a thin, hollowneedle, known as a cryoprobe, is inserted into the targeted breast tumor under local anesthesia. A freeze-thaw-freeze cycle with temperatures as lowas - 170 ° C destroys cancerous tissue alongwith an additional margin of healthy tissue. After the procedure, women cangenerally resume normal activities with little to no recovery time. The tumor becomes necrotic, and the body absorbs the dead tissue over time. There is little or no change to the cosmetic appearance of thebreast. Adjuvant therapy such as oral hormone blocker or radiation is complementary to cryoablation. IceCure is conducting the ICE 3 Clinical Trial, the largest multi-center trial for cryoablation of small, low-risk breast cancer. Interimanalysis of the ICE 3 trial presented during ASBrS 2021 Annual Meeting show promising results - at a mean of 34 . 83 months following treatment with ProSense ™ , only 2 . 06 %( 4 out of 194 eligible trial patients) experienced cancer recurrence. Cryoablation in Interventional Oncology IceCure’s ProSense ™ Systemoffers a unique solution in thefield of interventional oncology, with special emphasis in the treatment of kidney, lung, andpalliative bone cancer treatments. These types of cryoablation treatments are generally performed under CT (Computed Tomography) guidancewith light sedation and patients can usually go home the same day. Compared to other cryoablation systems that useArgon gas andmultiple cryoprobes, ProSense ™ utilizes liquid nitrogen (a superior coolant), and a single cryoprobe. The cryoprobe can be relocated up to 3 times to create large ice balls or treat multiple areas with better cost- effectiveness. The procedure has an exceptional safety profilewithminimal pain as the ice ball has an analgesic effect and treatment can be repeated if necessary. Strong Relationship and Commitment to India Thanks to the support of the Israel Trade & Economic Mission to India, the Consulate General of Israel in Mumbai, and collaboration with the Government of Maharashtra, a ProSense ™ Cryoablation System was donated to TataMemorial Hospital. Apercentage of the treatments provided will be free of charge for people in India who could otherwise not afford cryoablation. IceCureMedical remains dedicated to further developing partnerships in India to provide better access to our innovative cryoablation technology. www.icecure-medical.com E: info@icecure-medical.com ● P: + 972 - 4 - 623 - 0333 IceCure Medical: Freezing Cancer in its Tracks IceCure Medical is setting new standards in minimally invasive cryotherapy for women’s health and interventional oncology IceCure Medical < Medical Technologies < 75

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